Category Archives: Uncategorized

S2E2 Into the Endocannabinoidome



In this episode we journey beyond Cannabis and the endocannabinoid system into the endocannabinoidome! The endocannabinoidome is a relatively new concept used to describe the vast hundreds of compounds involved in the functioning of endocannabinoids and cannabinoid receptors. Learn about how this concept of the endocannabinoidome was formed, what clinicians think about its discovery, and what we can expect from the future of endocannabinoidome research! Plus hear an often overlooked story about the origin of “the entourage effect” and how the concept has been redefined for popular culture.

Featuring a contribution from Raphael Mechoulam, PhD via email and relevant excerpts from behind-the-scenes episodes:

BTS #5 Ethan Russo, MD

BTS #31 The Doctors Knox

BTS #35 Vincenzo Di Marzo, PhD

 

Stay curious, and take it easy!


BTS #37 Marcus “Bubbleman” Richardson on Bubble Hash, Legacy in Cannabis, Defense of Isolates



In this behind-the-scenes episode we join Cannabis culture icon Marcus “Bubbleman” Richardson. In the mid 1990s, he was one of the first to receive an industrial hemp license in Canada and began performing research and development with hemp varieties of Cannabis very early in his career. Marcus is also the producer of “bubble bags” and popularized bubble hash in the late 1990s and early 2000s. In 2014 he started a weekly long-form Cannabis show called Hash Church, which had a huge influence on Cannabis culture and the development of Cannabis extraction technology. Marcus is also a photographer and has an extensive library of macro photos of Cannabis trichomes and other curious odds and ends.

In our conversation we talked about the science of hash making, Marcus’ legacy in the Cannabis industry, lessons he has learned, the battle between full spectrum and cannabinoid isolates, and much more!

Learn more about Marcus’ work at www.bubblemanbrand.com


BTS #36 Anna Schwabe PhD on Sources of Variation in Cannabis Plants, Hope for Indica/Sativa?



In this behind-the-scenes episode we join Anna Schwabe, PhD, a geneticist and plant scientist that spent her PhD work examining how and why Cannabis plants exhibit different chemical profiles, smells, and effects. In our conversation we dive into many of these nuances and talk about whether people can distinguish Cannabis varieties consistently by smell, how much variation exists between Cannabis plants labeled as the same strain, and whether there may be some hope after all for the colloquial use of the terms “indica” and “sativa”.

Learn more about Anna’s work at www.annaschwabe.com


S2E1 An Introduction to Extraction Science and Technology



In this episode, we dive into the world of Cannabis extraction science and technology to understand how Cannabis extracts are made, why there are so many different types of extracts, the science behind extraction, and how to make sense of marketing terms like “full spectrum”, “broad spectrum”, or “whole plant”.

Featuring excerpts from our behind-the-scenes interviews with:

  • Marcus “Bubbleman” Richardson (Hash Maker and Cannabis Aficionado)
  • Wyeth Callaway, PhD (Organic Chemist)
  • Murphy Murri (Extraction Technologist)
  • Daniel Hayden, PhD (Molecular Plant Biologist)
  • Travis Simpson (Herbal Scientist)

S2E1 Promo: “Extraction Jackson, What’s That Fraction?”



What do you really know about Cannabis extracts? In episode one of season two, we dive into the world of Cannabis extraction science and technology to understand how Cannabis extracts are made, why there are so many different types of extracts, the science behind extraction, and how to make sense of marketing terms like “full spectrum”, “broad spectrum”, or “whole plant”.

Featuring excerpts from our behind-the-scenes interviews with:

  • Marcus “Bubbleman” Richardson (Hash Maker and Cannabis Aficionado)
  • Wyeth Callaway, PhD (Organic Chemist)
  • Murphy Murri (Extraction Technologist)
  • Daniel Hayden, PhD (Molecular Plant Biologist)
  • Travis Simpson (Herbal Scientist)

Catch Season 2 Episode 1 on Monday, November 9th, 2020! Visit www.CACPodcast.com for more info.


BTS #35 Vincenzo Di Marzo, PhD on the Endocannabinoid System and the Endocannabinoidome



In this behind-the-scenes episode we join renowned endocannabinoid researcher Dr. Vincenzo Di Marzo, who has been studying endocannabinoids since their discovery in the late 1980s and 1990s. Dr. Di Marzo, along with his colleagues, originally proposed the concept of the endocannabinoid system, the entourage effect, and the endocannabinoidome. Currently Dr. Di Marzo is working on studying the relationships between endocannabinoids and the gut microbiome to better understand how cannabinoids may affect health through the gut. In our conversation we discuss Dr. Di Marzo’s fascination with endocannabinoids, how he conceptualizes the endocannabinoidome, common misunderstandings about endocannabinoids, how the concept of the “entourage effect” has evolved away from its original intended meaning, where the future of Cannabis research may be heading, and much more.

This was a career highlight of mine to be able to talk to Vincenzo and I am honored to share this conversation with you. Enjoy!


BTS #34 Sher Ali Butt of CB Therapeutics on Biosynthesizing Cannabinoids and Psychedelics



In this behind-the-scenes interview we sit down with Sher Ali Butt, the co-founder of CB Therapeutics, a company focused on biosynthesizing cannabinoids and psychedelics using fermentation with fungi. We talk about the science behind biosynthetic technology, why they have chosen to focus on psychedelics and cannabinoids, how biosynthesis compares to chemical synthesis techniques for producing compounds, why isolated compounds and complex herbal mixtures can both have a place in healthcare, and much more!

Learn more about CB Therapeutics at www.cbthera.com


Welcome to The Curious About Cannabis Podcast (Trailer)



It’s a plant that goes by many names. Some call it hemp. Some call it marijuana. Call it what you will – it’s Cannabis, and it’s got a lot of people curious. Join scientist and educator Jason Wilson on a journey to explore critical questions about the world’s most controversial plant. Featuring contributions from leading researchers, doctors, and industry veterans alike – prepare to cut through the hype to uncover lasting insights about Cannabis.

Welcome to the Curious About Cannabis Podcast!

Visit CACPodcast.com for more content and follow Curious About Cannabis on Instagram, Facebook and Twitter


BTS #33 Alice Moon on Cannabinoid Hyperemesis, Cannabis Branding, Social Equity



In this behind-the-scenes episode we are joined with Alice Moon, a PR professional working in the Cannabis industry and diagnosed cannabinoid hyperemesis patient. In our conversation we discuss her entrepreneurial journey within the Cannabis industry that led to her work in public relations, issues facing Cannabis brands, her experience with cannabinoid hyperemesis syndrome, what she has learned about the disorder since being diagnosed, work that she is doing to try and understand the disorder, how she responds to criticisms from the Cannabis industry, words of advice for those who are worried that they may be suffering from CHS, and more!

To learn more about Alice Moon visit www.alicemoon.la

To learn more about cannabinoid hyperemesis syndrome, visit www.cannabinoid-hyperemesis.com


BTS #32 Mark Scialdone PhD on Cannabis Chemistry History, Hydrogenated Cannabinoids, Science and Art



In this behind-the-scenes episode we sit down with Mark Scialdone PhD, a chemist responsible for inventing hydrogenated cannabinoid acids, semi-synthetic cannabinoids that could be effective at battling certain types of cancer. We discuss the history of cannabinoid science, controversy around cannabinoid boiling points, how Mark learned from his research with catnip essential oil hydrogenation and how he adapted the technology for Cannabis essential oil, the importance of balancing science with art, the future of Cannabis research, his role in helping the American Chemical Society’s Cannabis Chemistry subdivision get started, and much more.

This episode was cut for time. To listen to the extended 2+ hour version, visit www.Patreon.com/CuriousAboutCannabis